Long term resident on my hard drive, XP-Antispy which also supports Vista & Win7, disables or removes a slew of features that do nothing for performance, privacy or security. The interface is straight-forward and all the relevant options are explained. Usually first run after windows installations. Note that you need administrator rights for some actions which can be activated in the 'Special' menu.
The rather good and free
CCleaner which removes the gash files smothered all over your hard drive has been updated with the following changes:
Here's the current beta version of to the rather good and free
CCleaner which removes the gash files smothered all over your hard drive with the following changes:

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